|
1.
Mason, F.R., Leong, F-C., Plaxco, K.W. and Morton, T.H. (1985) ÒTwo n
covalent modification of proteins: Selective labeling of Schiff base forming
sites and selective blockade of the sense of smell in vivo.Ó J. Am. Chem. Soc., 107, 6075-6084
2.
Plaxco, K.W., Mathiowetz, A.A. and Goddard, W.A. (1989) ÒPredictions of
structural elements for the binding of hin recombinase with the hix site of DNA.Ó Proc. Nat. Acad. Sci. USA, 86,
9841-9845
3.
Plaxco, K.W. and Goddard, W.A. III (1994) ÒContributions of the thymine
methyl group to the specific recognition of poly- and mono-nucleotides: An analysis
of the relative free energy of solvation of thymine and uracil.Ó Biochemistry, 33, 3050-3054
1996
4.
Plaxco, K.W., Spitzfaden, C., Campbell, I.D. and Dobson, C.M. (1996)
ÒRapid folding of a proline rich, all beta-sheet fibronectin type III domain.Ó Proc.
Natl. Acad. Sci. USA, 93, 10703-10706
5.
Plaxco, K.W. and Dobson, C.M. (1996) ÒTime-resolved biophysical methods
in the study of protein folding.Ó Curr.
Opin. Struc. Biol., 6, 630-636
1997
6.
Plaxco, K.W., Spitzfaden, C., Campbell, I.D. and Dobson, C.M. (1997)
ÒComparison of the folding kinetics and thermodynamics of two homologous
fibronectin type III modules.Ó J. Mol.
Biol. 270, 763-770
7.
Plaxco K.W. and Gross, M. (1997) ÒThe importance of being unfolded.Ó Nature, 386, 657-659
8.
Plaxco, K.W., Morton, C.J., Grimshaw, S., Jones, J.A., Pitkeathly, M.,
Campbell, I.D. and Dobson, C.M. (1997) ÒThe effects of guanidine hydrochloride
on the Ôrandom coilÕ conformations and NMR chemical shifts of the peptide
series GGXGG.Ó J. Biomolec. NMR, 10, 221-230
9.
Gross, M. and Plaxco, K.W. (1997) ÒProtein engineering: reading,
writing and re-designing.Ó Nature, 367, 419-420
10.
O'Brien, R., Wynn, R.,
Driscoll, P.C., Davis, B., Plaxco, K.W., Sturtevant, J.M. and Ladbury, J.E.
(1997) ÒThe adaptability of Escherichia coli thioredoxin to non-conservative
amino acid substitutions.Ó Prot. Sci., 6, 1325-133
1998
11.
Plaxco, K.W., Guijarro,
J.I., Morton, C.J., Pitkeathly, M., Campbell, I.D. and Dobson, C.M. (1998) ÒThe
folding kinetics and thermodynamics of the FynSH3 domain.Ó Biochemistry, 37, 2529-2537
12.
Guijarro, J.I., Morton,
C.J., Plaxco, K.W., Campbell, I.D. and Dobson, C.M. (1998) ÒFolding kinetics of
the SH3 domain of PI3 by real-time NMR and optical techniques.Ó J. Mol. Biol., 275, 657-667
13.
Plaxco, K.W., Riddle, D.S.,
Grantcharova, V. and Baker, D. (1998) ÒSimplified proteins: Minimalist
solutions of the Ôprotein folding problemÕ.Ó Curr. Op. Struct. Biol, 8, 80-85
14.
Plaxco, K.W., Simons, K.T.
and Baker, D. (1998) ÒContact order, transition state placement and the
refolding rates of single domain proteins.Ó J.
Mol. Biol., 277, 985-994
15.
Plaxco, K.W. (1998) ÒProtein
chemistry comes of age. Again.Ó Trends in Biotech., 16, 278
16.
Plaxco, K.W. and Baker, D.
(1998) ÒLimited internal friction in the rate limiting conformational change of
a two-state protein folding reaction.Ó Proc.
Natl. Acad. Sci. USA, 95,
13591-13596
17.
Plaxco, K.W. and Dobson,
C.M. (1998) ÒMonitoring protein folding using time-resolved biophysical
techniques.Ó in Protein Dynamics, Function and Design, O. Jardetzky and
J. Lefevre, eds., Plenum Press, New York, pp 331-332
1999
18.
Plaxco, K.W., Millett, I.S.,
Segel, D.J., Doniach, S. and Baker, D. (1999) ÒPolypeptide chain collapse can
occur concomitantly with the rate limiting step in protein folding.Ó Nat. Struct. Biol., 6, 554-557
19.
Viani, M.B., Schaffer, T.E.,
Paloczi, G.T., Pietrasanta, L., Smith, B.L, Thompson, J.B., Reif, M., Gaub,
H.E., Plaxco, K.W., Cleland, A., Hansma, H.G. and Hansma, P.K. (1999) ÒFast
imaging and fast force spectroscopy of single biopolymers with anew atomic
force microscope designed for small cantilevers.Ó Rev. Sci. Inst., 70,
4300-4303
2000
20.
Plaxco, K.W., Larson, S.,
Ruczinski, I., Riddle, D.S., Thayer, E.C., Buchwitz, B., Davidson, A.R. and
Baker, D. (2000) ÒEvolutionary conservation in protein folding kinetics.Ó J. Mol. Biol., 298, 303-312
21.
Plaxco, K.W., Simons, K.T.,
Ruczinski, I. and Baker, D. (2000) ÒSequence, stability, topology and length;
the determinants of two-state protein folding kinetics.Ó Biochemistry, 39,
11177–11183
22.
Gillespie, B. and Plaxco,
K.W. (2000) ÒNon-glassy kinetics in the folding of a simple, single domain
protein.Ó Proc. Natl. Acad. Sci. USA, 97, 12014-12019
2001
23.
Plaxco, K.W. and Gross, M.
(2001) ÒUnfolded, yes, but random? Never!Ó Nat.
Struct. Biol., 8, 659-670
2002
24.
Millet, I.S., Townsley, L.,
Chiti, F., Doniach, S. and Plaxco, K.W. (2002) ÒEquilibrium collapse and the
kinetic ÔfoldabilityÕ of proteins.Ó Biochemistry, 41, 321-325
25.
Makarov, D.E., Keller, C.A.,
Plaxco, K.W. and Metiu, H. (2002) ÒHow the folding rate constant of
simple-single domain proteins depends on number of native contacts.Ó Proc. Natl. Acad. Sci. USA, 99, 3535-3539
26.
Larson, S., Ruczinski, I.,
Davidson, A.R., Baker, D. and Plaxco, K.W. (2002) ÒResidues
participating in the protein folding nucleus do not exhibit preferential evolutionary
conservation.Ó J. Mol. Biol., 316, 225-233
27.
Fan, C., Plaxco, K.W. and
Heeger, A.J. (2002) ÒHigh-efficiency fluorescence quenching of conjugated
polymers by proteins.Ó J. Am. Chem. Soc., 124, 5642-5643
28.
Thompson, J.B., Hansma,
H.H., Hansma, P.K. and Plaxco, K.W. (2002) ÒThe backbone conformational entropy
of protein folding: experimental measures from atomic force microscopy.Ó J. Mol. Bio., 322, 645-652
29.
Millett, I.S., Doniach, S.
and Plaxco, K.W. (2002) ÒTowards a taxonomy of the denatured state: small angle
scattering studies of unfolded proteins.Ó Adv.
Prot. Chem., 62, 241-262
30.
Fan, C., Gillespie, B.,
Wang, G., Heeger, A.J. and Plaxco, K.W. (2002) ÒSpectroscopy and
electrochemistry of the pyridine-chytochrome c complex and the pyridine-induced
Ôalkaline-likeÕ conformation.Ó J. Phys. Chem. B, 106, 11375-11383
2003
31.
Makarov, D.E. and Plaxco,
K.W. (2003) ÒThe topomer search model: a quantitative, first-principles
description of two-state protein folding kinetics.Ó Prot. Sci., 12, 17-26
32.
Jewett, A., Pande, V.S. and
Plaxco, K.W. (2003) ÒCooperativity, smooth energy landscapes and the origins of
topology-dependent protein folding rates.Ó J.
Mol. Bio., 326, 247-253
33.
Fan, C., Hirasa,
T., Plaxco, K.W. and Heeger, A.J. (2003) ÒPhotoluminescence quenching of water-soluble
conjugated polymers by viologen derivatives: effect of hydrophobicity.Ó Langmiur, 19, 3554-3556
34.
Fan, C., Wang, S., Hong,
J.M., Bazan, G.C., Plaxco, K.W. and Heeger, A.J. (2003) ÒBeyond superquenching:
hyper-efficient energy transfer from conjugated polymers to gold nanoparticles.Ó Proc.
Natl. Acad. Sci. USA, 100, 6297-6301
35.
Calloni, G., Taddei, N., Plaxco, K.W., Ramponi, G., Stefani, M. and
Chiti, F. (2003) ÒComparison of the folding processes of distantly related proteins.
Importance of hydrophobic content in folding.Ó J.
Mol. Bio., 330, 577-591.
36.
Gillespie, B., Vu, D., Shah,
P.S., Marshall, S., Dyer, R.B., Mayo, S.L., and Plaxco, K.W. (2003) ÒNMR and
Temperature Jump measurements of de novo designed proteins demonstrate rapid folding in the absence of explicit
selection for kinetics.Ó J. Mol. Bio., 330, 813-819
37.
Fan, C., Plaxco, K.W. and
Heeger, A.J. (2003) ÒElectrochemical interrogation of conformational changes as
a reagentless method for the sequence-specific detection of DNA.Ó Proc. Natl. Acad. Sci. USA, 100, 9134-9137
38.
Ivankov, D.N., Alm, E.,
Plaxco, K.W., Baker, D. and Finkelstein, A.V. (2003) ÒContact order revisited:
the influence of protein size on folding rates.Ó Prot. Sci., 12, 2057-2062
39.
Xu, J., Ramian, G.J., Galan,
J.F., Savvidis, P.G., Scopatz, A.M., Birge, R.R. Allen, S.J. and Plaxco, K.W.
(2003) ÒTerahertz circular dichroism spectroscopy: a potential approach to
unbiased, in situ life detection.Ó Astrobiology, 3,
489-504
2004
40.
Gillespie, B. and Plaxco,
K.W. (2004) ÒUsing protein folding rates to test protein folding theories.Ó Ann. Rev. Biochem. Biophys., 73, 837-859
41.
Kohn, J.E., Millett, I.S.,
Jacob, J., Zagrovic, B., Dillon, T., Cingel, N., Seifert, S.,
Thiyagarajan, P., Sosnick. T.R., Ruczinski, I., Hasan, M.Z., Pande, V.S.
Doniach, S. and Plaxco, K.W (2004) ÒDo the dimensions of chemically unfolded
proteins differ significantly from the expectations of a random-coil model?Ó Proc. Natl. Acad. Sci. USA, 101, 12491-12496
42.
Gillespie, B. and Plaxco,
K.W. (2004) ÒCan theory predict two-state protein folding rates? An
experimental perspective.Ó In: Forces, Growth and Form in Soft Condensed
Matter: At the Interface between Physics and Biology, Skjeltorp, A.T. and Velushkin, A.V., Eds, Kluwer Academic
Publishers BV, Dordrecht, Netherlands, pp
93-111
43.
Xu, J., Ramian, G.J., Galan,
J.F., Savvidis, P.G., Scopatz, A.M., Birge, R.R., Allen, S.J. and Plaxco, K.
(2004) ÒTerahertz circular dichroism spectroscopy of biomolecules.Ó In: Chemical and Biological Standoff Detection. J.O. Jensen and J-M. Theriault, Eds. Proceedings of the
SPIE, Vol. 5268, pp 19-26
2005
44.
Raleigh, D.S. and Plaxco,
K.W. (2005) ÒPlasticity and heterogeneity in the folding nucleus; what are f-values really telling us?Ó Prot. Pep. Sci., 12, 117-122
45.
de los Rios, M.A. and
Plaxco, K.W. (2005) ÒApparent Debye-Huckel electrostatic effects in the folding
of a simple, single domain protein.Ó Biochemistry, 44, 1243-1250
46.
Maxwell, K.L., Wildes, D.,
Zarrine-Afsar, A., de los Rios, M.A., Brown, A.G., Friel, C.T, Hedberg, L.,
Horng, J-C., Bona, D., Miller, E.J., VallŽe-BŽlisle, A., Main, E.R.G., Bemporad,
F., Qiu, L., Teilum, K., Vu, N.-D., Edwards, A.M., Ruczinski, I., Poulsen,
F.M., Kragelund, B.B., Michnick, S.W., Chiti, F., Bai, Y., Hagen, S.J.,
Serrano, L., Oliveberg, M., Raleigh, D.P., Wittung-Stafshede, P., Radford,
S.E., Jackson, S.E., Sosnick, T.R., Marqusee, S., Davidson, A.R., Plaxco, K.W.
(2005) ÒProtein folding: defining a ÔstandardÕ set of experimental conditions
and a preliminary kinetic data set of two-state proteins.Ó Prot. Sci., 14,
602-616
47.
Fan, C., Plaxco, K.W. and
Heeger, A.J. (2005) ÒLigand-modulated electron- or energy-transfer as a
biosensor signaling mechanism.Ó Trends
Biotech., 23,186-192
48.
Kohn, J.E. and Plaxco, K.W.
(2005) ÒEngineering of a signal-transduction mechanism for protein-based
biosensors.Ó Proc. Natl. Acad. Sci. USA, 102, 10841-10845
49.
McCarney, E.R., Kohn, J.E.
and Plaxco, K.W. (2005) ÒIs there or isnÕt there? The case for (and against) residual structure in chemically
denatured proteins.Ó Crit. Rev. Bioch.
Mol. Biol., 40, 181-189
50.
Xiao, Y., Lubin, A.A.,
Heeger, A.J. and Plaxco, K.W. (2005) ÒLabel-free electronic detection of
thrombin in blood serum using an aptamer based sensor.Ó Angw. Chem. Int. Ed., 44,
2-5
51.
McCarney, E.R., Werner,
J.H., Ruczinski, I., Makarov, Goodwin, P.M. and Plaxco, K.W. (2005) ÒRandom
coil dimensions in a highly denatured protein; A single molecule study.Ó J. Mol. Biol., 352,
672-682
52.
de los Rios, M.A., Danashi,
M. and Plaxco, K.W. (2005) ÒExperimental investigation of the frequency and
substitution dependence of negative f-values in two-state proteins.Ó Biochemistry, 44, 12160 -12167
53.
Xiao, Y., Piorek, B.D.,
Plaxco, K.W. and Heeger, A.J. (2005) ÒA reagentless, signal-on design for
electronic aptamer-based sensors via target-induced strand displacement.Ó J. Am. Chem. Soc., 127, 17990-17991
2006
54.
Xu, J., Plaxco, K.W. and
Allen, S.J. (2006) ÒAbsorption spectra of liquid water and aqueous buffers
between 0.3 - 3.72 terahertz.Ó J. Chem.
Phys. 124, 036101
55.
de los Rios, M.A.,
Muralidhara, B.K., Wildes, D., Marqusee, S., Wittung-Stafshed, P., Plaxco, K.W.
and Ruczinski, I. (2006) ÒOn the precision of experimentally determined folding
rates and f-values.Ó Prot.
Sci., 15, 553-563
56.
Lai, R.Y, Lee, S-H., Soh,
H., Plaxco, K.W. and Heeger, A.J. (2006) ÒDifferential labeling of
closely-spaced biosensor electrodes via electrochemical lithography.Ó Langmiur, 22,
1932-1936
57.
Lai, R.Y., Lagally, E.T.,
Lee, S.-H., Soh, T.H., Plaxco, K.W. and Heeger, A.J. (2006) ÒRapid,
sequence-specific detection of unpurified PCR amplicons via a reusable, electrochemical sensor.Ó Proc.
Natl. Acad. Sci. USA, 103,
4017-4021
58.
Baker, B.R., Lai, R.Y.,
Wood, M.S., Doctor, E.H., Heeger, A.J. and Plaxco, K.W. (2006) ÒAn electronic,
aptamer-based small molecule sensor for the rapid, reagentless detection of
cocaine in adulterated samples and biological fluids.Ó J. Am. Chem. Soc. 128, 3138-3139
59.
Xu, J., Plaxco, K.W. and Allen, S.J. (2006) ÒProbing the collective
vibrational dynamics of a protein in liquid water by terahertz absorption
spectroscopy.Ó Prot. Sci, 15,
1175-1181
60.
Faisca, P.F.N. and Plaxco,
K.W. (2006) ÒCooperativity and the origins of rapid, single-exponential
kinetics in protein folding.Ó Prot. Sci., 15, 1608-1618
61.
Lubin, A.A, Lai, R.Y.,
Heeger, A.J. and Plaxco, K.W. (2006) ÒOn the sequence specificity, selectivity
and reusability of E-DNA, a reagentless, electronic DNA sensor.Ó Anal. Chem., 78,
5671-5677
62.
Ruczinski, I., Sosnick, T.R.
and Plaxco, K.W. (2006) ÒMethods for the accurate estimation of confidence
intervals on experimental f values.Ó Prot.
Sci., 15, 2257-2264
63.
Xiao, Y, Lubin, A.A., Baker,
B.R., Plaxco, K.W. and Heeger, A.J. (2006) ÒSingle-step
electronic detection of femtomolar DNA by target-induced strand displacement in
an electrode-bound duplex.Ó Proc.
Natl. Acad. Sci. USA, 103, 16677-16680
64.
Oh, K.J, Cash, K.J. and
Plaxco, K.W. (2006) ÒExcimer-based
peptide beacons; a convenient experimental approach for monitoring polypeptide-protein
and polypeptide-oligonucleotide interactions.Ó J. Am. Chem. Soc., 128, 14018-14019
65.
Seferos, D.S., Lai, R.Y.,
Plaxco, K.W. and Bazan, G.C. (2006) Òa,w-Dithiol
oligo(phenylenevinylene)s for the preparation of high-quality conjugated SAMs
and nanoparticle functionalized electrodes.Ó Adv. Funct. Mat., 16, 2387–2392
66.
Lai, R.Y, Seferos, D.S.,
Heeger, A.J., Bazan, G.C. and Plaxco, K.W. (2006) ÒComparison
of the signaling and stability of electrochemical DNA sensors fabricated from
6- or 11-carbon self-assembled monolayers.Ó Langmuir, 22, 10796-10800
67.
Xu, J., Plaxco, K.W. and
Allen, S.J. (2006) ÒThe collective dynamics of lysozyme in water: terahertz
absorption spectroscopy and comparison with theory.Ó J. Phys. Chem,, 110, 24255-24259
2007
68.
Lai, R.Y., Plaxco, K.W. and
Heeger, A.J. (2007) ÒRapid, aptamer-based electrochemical detection of
platelet-derived growth factor at picomolar concentrations directly in blood
serum.Ó Anal. Chem., 79, 229-233
69.
Xu, J., Plaxco, K.W., Allen,
S.J., Bjarnason, J.E. and Brown, E.R. (2007) Ò0.15 – 3.72 terahertz
absorption of aqueous salts and saline solutions.Ó J. Chem. Phys., 90, 031908
70.
Xiao, Y., Rowe, A.A. and
Plaxco, K.W. (2007) ÒElectrochemical detection of parts per billion lead via an
electrode-bound DNAzyme assembly.Ó J. Am.
Chem. Soc., 129, 262 – 263
71.
Plaxco, K.W. (2007) ÒA
biologistÕs perspective on Astrobiology.Ó Guest essay in Universe, 8th Ed by Freedman, R.A and Kaufmann, W.J., W.H. Freeman & Company, New York,
NY, pp. 28-17
72.
Werner, J.H., McCarney,
E.R., Keller, R.A., Plaxco, K.W. and Goodwin, P.M. (2007) ÒIncreasing the
resolution of single pair energy transfer measurements.Ó Anal. Chem., 79, 3509-3513
73.
Oh, K.J., Cash, K.J.,
Hugenberg, V. and Plaxco, K.W. (2007) ÒPeptide
beacons: A new design for polypeptide-based optical biosensors.Ó Bioconj. Chem., 18,
607-609
74.
Ricci, F., Lai, R.Y.,
Heeger, A.J., Plaxco, K.W. and Sumner, J.J. (2007) ÒEffect of molecular
crowding on the response of an electrochemical DNA sensor.Ó Langmuir, 23,
6827-6834
75.
Wang,
Z., Plaxco, K.W., and Makarov, D.E. (2007) ÒInfluence of local, residual
structure on the scaling behavior and dimensions of unfolded proteins.Ó Biophys. J., 86,321-328
76.
Ricci, F., Lai, R.Y. and
Plaxco, K.W. (2007) ÒLinear, redox modified DNA probes as electrochemical DNA
sensors.Ó Chem. Comm., 3768-3770
77.
Xiao, Y., Qu, X., Plaxco,
K.W. and Heeger, A.J. (2007) ÒLabel-free electrochemical detection of DNA in
blood serum via target-induced resolution of an electrode-bound DNA
pseudoknot.Ó J. Am. Chem. Soc., 129, 11896 - 11897
78.
Xiao, Y., Lai, R.Y., and Plaxco, K.W. (2007) ÒPreparation of
electrode-immobilized, redox-modified oligonucleotides for electrochemical DNA
and aptamer-based sensing.Ó Nature Prot., 2, 2875 - 2880
79.
Oh, K. J., Cash, K.J.,
Lubin, A.A. and Plaxco, K.W. (2007) ÒChimeric peptide beacons: a direct
polypeptide analog of DNA molecular beacons.Ó Chem. Comm., 4869 - 4871
2008
80.
Xu, J., Plaxco, K.W. and Allen, S.J. (2008) ÒTHz spectroscopy of
proteins in water: direct absorption and circular dichroism.Ó Int. J. High Speed Elec. Sys., 17, 709-718
81.
Lubin, A.A., Fan, C., Schafer, M., Clelland, C.T., Bancroft, C.,
Heeger, A.J. and Plaxco, K.W. (2008) ÒRapid, electronic detection of DNA and
non-natural DNA analogs for molecular marking applications.Ó For. Sci. Comm., 10 (1)
82.
Pavlovic, E., Lai, R.Y., Wu,
T.T., Ferguson, B.S., Sun, R., Plaxco, K.W. and Soh, H.T. (2008) ÒSpecific,
electrochemical detection of multiple DNA sequences in an integrated
microfluidic system.Ó Anal. Chem., 24, 1102 –
1107
83.
Pavel, I., McCarney, E.,
Elkhaled, A., Morrill, A., Plaxco, K. and Moskivits, M. (2008) ÒLabel-free SERS
detection of small proteins modified to act as bifunctional linkers.Ó J. Phys. Chem., 112, pp
4880 - 4883
84.
White, R.J., Phares, N.,
Lubin, A.A. Xiao, Y. and Plaxco, K.W. (2008) ÒOptimization of electrochemical aptamer-based
sensors by controlling surface probe densities and surface attachment
chemistry.Ó Langmuir, 24, 10513–10518
85.
Ricci, F. and
Plaxco, K.W. (2008) ÒE-DNA: a convenient, label-free method for the
electrochemical detection of hybridization.Ó Microchim. Acta, 163,
149-155
2009
86.
Ruczinski, I. and Plaxco,
K.W. (2009) ÒSome recommendations for the practitioner to improve the precision
of experimentally determined protein folding rates and f values.Ó Proteins, Struc. Func. Genet., 74, 461-474
87.
Plaxco, K.W. and Gross, M.
(2009) ÒProtein complexes: The evolution of symmetry.Ó Curr. Biol., 19, R25-26
88.
Cash, K.J., Heeger, A.J.,
Plaxco, K.W. and Xiao, Y. (2009) ÒOptimization of a reusable, DNA pseudoknot-based
electrochemical sensor for sequence-specific DNA detection in blood serum.Ó Anal. Chem., 81, 656-661
89.
Phares, N., White, R.J. and
Plaxco, K.W. (2009) ÒImproving the stability and sensing of electrochemical
biosensors by employing trithiol-anchoring groups in a six-carbon
self-assembled monolayer.Ó Anal. Chem., 81, 1095-1100
90.
Ricci, F., Bonham, A.J.,
Reich, N.O. and Plaxco, K.W. (2009) ÒA reagentless, electrochemical approach
for the specific detection of double- and single-stranded DNA binding
proteins.Ó Anal. Chem., 81, 1608-1614
91.
Oh, K.J., Cash, K.J. and
Plaxco, K.W. (2009) ÒBeyond Molecular Beacons: optical sensors based on the
binding-induced folding of proteins and polypeptides.Ó Chem. Europ. J., 15,
2244-2251
92.
Xiao, Y. and Plaxco, K.W.
(2009) ÒElectrochemical aptamer
sensors.Ó in: Functional nucleic acids for sensing and other analytical
applications, Y. Lu and Y. Li, Eds. pp 179-198, Springer, New York
93.
Lubin, A.A., Vander Stoep Hunt, B. and Plaxco,
K.W. (2009) ÒThe effects of probe
length, probe geometry and redox-tag placement on the performance of the
electrochemical E-DNA sensor .Ó Anal.
Chem., 81, 2150–2158
94.
Plaxco, K.W. (2009) ÒBreaking symmetry.Ó Chem. World, 6, 61
95.
Swenson, J.S., Xiao, Y., Ferguson,
B.S., Lai, R.Y., Heeger, A.J., Plaxco, K.W. and Soh, T. (2009) ÒContinuous,
real-time monitoring of cocaine in undiluted, unmodified blood serum via a microfluidic, aptamer-based sensor.Ó J. Am. Chem. Soc., 131, 4262–4266
96.
White, R.J. and Plaxco, K.W.
(2009) ÒEngineering new aptamer geometries for electrochemical aptamer-based
sensors.Ó In: Proc. SPIE Bio-Inspired/Biomimetic Sensor Technologies and
Applications, N.F. Fell and V.S. Swaminathan Eds., 7321, 5.1-5.9
97.
Cash, K.J., Ricci, F. and
Plaxco, K.W. (2009) ÒAn electrochemical sensor for the detection of
protein-small molecule interactions directly in serum and other complex
matrices.Ó J. Am. Chem. Soc., 131, 6955-6957
98.
Zuo,
X., Xiao, Y. and Plaxco, K.W. (2009) ÒHigh specificity, electrochemical sandwich
assays based on single aptamer sequences and suitable for the direct detection of
small-molecule targets in blood and other complex matrices.Ó J. Am. Chem. Soc., 131, 6944-6945
99.
Xiao, Y., Uzawa, T., White, R.J., DeMartini, D. and
Plaxco, K.W. (2009) ÒOn the signaling of electrochemical, aptamer-based
sensors: collision- and folding-based mechanisms.Ó Electroanalysis, 21, 1267 – 1271
100.
Xiao, Y., Plakos, J.J.I.,
Lou, X., Qian, J., White, R.J., Plaxco, K.W. and Soh, H.T. (2009) ÒFluorescence detection of single-nucleotide
polymorphisms with a single, self-complementary, triple-stem DNA probe.Ó Angewante, 48, 4354-4358
101.
Uzawa,
T., Cheng, R.R., Cash, K.J., Makarov, D.E. and Plaxco, K.W. (2009)
ÒCharacterization of the length and viscosity dependence of the end-to-end
collision dynamics of single-stranded DNA.Ó Biophys.
J., 97, 205-210
102.
Ricci, F., Zari, N., Caprio,
F., Recine, S., Amine, A., Moscone, D., Palleschi, G. and Plaxco, K.W. (2009)
ÒSurface chemistry effects on the performance of an electrochemical DNA
sensor.Ó Bioelectrochemistry, 76, 208-213
103.
VallŽe-BŽlisle, A., Ricci, F. and Plaxco,
K.W. (2009) ÒThermodynamic basis for
the optimization of binding-induced
biomolecular switches and structure-switching biosensors.Ó Proc. Natl. Acad. Sci. USA, 106,
13802-13807
104.
Makarov, D.E. and Plaxco,
K.W. (2009) ÒMeasuring distances within unfolded biopolymers using fluorescence
resonance energy transfer: The effect of polymer chain dynamics on the observed
fluorescence resonance energy transfer efficiency.Ó J. Chem. Phys., 131 Art.
No. 085105
105.
Cash, K.J., Ricci, F. and
Plaxco, K.W. (2009) ÒA general electrochemical method for label-free screening
of protein-small molecule interactions.Ó Chem.
Comm., 6222 - 6224
106.
Cheng, R.R., Uzawa, T.,
Plaxco, K.W. and Makarov, D.E. (2009) ÒThe rate of intramolecular loop
formation in DNA and polypeptides: The absence of the
diffusion-controlled limit and fractional power law viscosity dependence.Ó J. Chem. Phys. B, 113, 14026–14034
107.
Kohn, J.E., Gillespie, B.
and Plaxco, K.W. (2009) ÒNon-sequence-specific interactions can account for the compaction of proteins unfolded under ÔnativeÕ
conditions.Ó J. Mol. Biol., 394, 343–350
108.
Xiao, Y., Lou, X.H., Uzawa, T., Plakos, K.J.I.,
Plaxco, K.W. and Soh, H.T. (2009) ÒAn electrochemical sensor for single
nucleotide polymorphism detection in serum based on a triple-stem DNA probe.Ó J. Am. Chem. Soc., 131,
15311-15316
109.
Kang, D., Zuo, X., Yang, R.,
Xia, F., Plaxco, K.W. and White, R.J. (2009) ÒComparing the properties of
electrochemical-based DNA sensors employing
different redox tags.Ó Anal. Chem., 81, 9109-9113
2010
110.
White, R.J. and Plaxco, K.W.
(2010) ÒExploiting binding-induced changes in probe flexibility for the
optimization of electrochemical biosensors.Ó Anal. Chem., 82, 73-76
111.
Kahn, K. and Plaxco, K.W.
(2010) ÒPrinciples of biomolecular recognition.Ó In: Recognition Receptors in Biosensors, M. Zourob, Ed., Springer, pp
3-45
112.
Xia, F., Zuo, X., Yang, R.,
Xiao, Y., Kang, D., VallŽe-BŽlisle, A., Gong, X., Heeger, A.J.
and Plaxco, K.W. (2010) ÒOn the binding of cationic, water-soluble conjugated
polyelectrolytes to DNA: electrostatic and hydrophobic
interactions.Ó J. Am. Chem. Soc., 132, 1252–1254
113.
White, R.J., Rowe, A.A., and
Plaxco, K.W (2010) ÒRe-engineering aptamers to support reagentless,
self-reporting electrochemical sensors.Ó The
Analyst, 135, 589-594
114.
Wickersham,
C.E., Cash, K.J., Pfeil, S.H., Bruck, I., Kaplan, D.L., Plaxco, K.W. and
Lipman, E.A. (2010) ÒTracking
a molecular motor with a nanoscale optical encoder.Ó Nano. Let., 10, 1022-1027
115.
Ricci,
F., Adornetto, G., Moscone, D., Plaxco, K.W. and Palleschi, G. (2010) ÒQuantitative, reagentless,
single-step electronic detection of anti-DNA antibodies directly in blood serum.Ó Chem. Comm., 46,
1742-1744
116.
Zuo, X., Xia, F., Xiao, Y.
and Plaxco, K.W. (2010) ÒA sensitive and selective, amplified fluorescent DNA
detection based on exonuclease III aided target recycling.Ó J. Am. Chem. Soc, 132, 1816-1818
117.
Lubin, A.A. and Plaxco, K.W.
(2010) ÒFolding-based electrochemical biosensors:
the case for responsive nucleic acid architectures.Ó Acc. Chem. Res., 43, 496–505
118.
Xia, F., Zuo, X., Yang, R., Xiao, Y., Kang, D., VallŽe-BŽlisle, A., Gong, X., Yuen, J.D.,
Hsu, B.Y., Heeger, A.J. and Plaxco, K.W. (2010) ÒColorimetric detection of DNA, small molecules,
proteins, and ions using unmodified gold nanoparticles and conjugated
polyelectrolytes.Ó Proc. Natl. Acad. Sci. USA, 107, 10837-10841
119.
Xia, F., Zuo, X., Yang, R.,
Xioa, Y., Kang, D., Gong, X., White, R., Lubin, A.A., VallŽe-BŽlisle, A., Yuen, J.D., Hsu,
Y.B.B. and Plaxco, K.W. (2010) ÒLabel-free, dual-analyte electrochemical
biosensors: a new class of molecular-electronic logic gates.Ó J. Am. Chem. Soc., 132, 8557–8559
120.
VallŽe-BŽlisle, A. and Plaxco, K.W. (2010)
ÒStructure-switching biosensors:
inspired by nature.Ó Curr. Op. Struc.
Biol., 20, 518-526
121.
Rowe, A.A., Miller, E. and
Plaxco, K.W. (2010) ÒRapid, reagentless measurement of aminoglycoside
antibiotics in blood serum via an electrochemical, RNA aptamer-based
biosensor.Ó Anal. Chem., 82, 7090–7095
122.
Lawrence, C., Kuge, J.,
Ahmad, K. and Plaxco, K.W. (2010) ÒInvestigation of an anomalously accelerating
substitution in the folding of a prototypical two-state protein.Ó J. Mol. Bio., 403, 446-458
123.
Abelow, A.E., Schepelina,
O., White, R.J., VallŽe-BŽlisle,
A., Plaxco, K.W. and Zharov, I. (2010) ÒBiomimetic glass nanopores.Ó Chem. Com., 46, 7984-7986
124.
Xia, F., White, R., Zuo, X.,
Patterson, A., Xiao, Y., Kang, D., Gong, X., Plaxco, K.W. and Heeger, A.J.
(2010) ÒAn electrochemical super-sandwich assay for sensitive and selective DNA
detection in serum.Ó J. Am. Chem. Soc., 132, 14346–14348
125.
Xiao, Y., Dane, K.Y., Uzawa,
T., Csordas, A., Qian, J., Soh, H.T., Daugherty, P.S., Lagally, E.T., Heeger,
A.J., and Plaxco, K.W. (2010) ÒDetection of telomerase activity in high
concentration of cell lysates using primer-modified gold nanoparticles.Ó J. Am. Chem. Soc., 132, 15299-15307
126.
Ricci, F., Caprio, F.,
Moscone, D., Plaxco, K.W. and Palleschi, G. (2010) ÒUsing triplex forming
oligonucleotide probes for the reagentless, electrochemical detection of double
stranded DNA.Ó Anal. Chem., 82, 9109–9115
127.
Uzawa, T., Cheng, R.R.,
White, R.J., Makarov, D.E and Plaxco, K.W. (2010) ÒA mechanistic study of electron transfer from the
distal termini of electrode-bound, single-stranded DNAs.Ó J. Am. Chem. Soc., 132, 16120–16126
128.
Plaxco,
K.W. (2010) ÒThe art of writing science.Ó Prot.
Sci., 19, 2261–2266
129.
Plaxco, K.W. and Soh, H.T.
(2010) ÒSwitch based biosensors: a new approach towards real-time, in vivo molecular detection.Ó Trends Biotech., In press.
130.
Cheng, R.R., Uzawa, T.,
Plaxco, K.W. and Makarov, D.E. (2010) ÒUniversality in the timescales of
internal loop formation in unfolded proteins and single-stranded
oligonucleotides.Ó Biophys. J., In
press.
1.
Plaxco, K.W. and Gross, M. (2006) Astrobiology; A Brief Introduction Johns Hopkins University Press.
2.
Plaxco, K.W. and Gross, M. (2011) Astrobiology; A Brief Introduction 2nd Ed., Johns Hopkins University Press, In press.
Patents:
1.
Plaxco, K.W. and Kayyem, J.F. ÒBiosensors utilizing ligand-induced
conformation changes.Ó Patent 6432723 Awarded 8/13/03
2.
Xiao, Y., Lubin, A., Plaxco, K.W. ÒA signal-on architecture for
electronic, oligonucleotide-based detectors.Ó Patent 7803542 Awarded 9/28/10
3.
Fan, F., Heeger, A.J. and Plaxco, K.W. ÒReagentless, reusable,
bioelectronic detectors.Ó Submitted 6/03