In the Han Lab, we are developing novel magnetic resonance concepts and techniques that enables one to detect and monitor smaller quantities, larger molecules and faster processes than conventionally feasible. The underlying principle is to utilize high electron spin polarization of various nitroxide spin labels to enhance the nuclear magnetic resonance (NMR) signal of sensor atoms and molecules; this principle is known as dynamic nuclear polarization (DNP). We combine novel DNP approaches, CW and pulsed electron spin resonance (ESR) at 10, 200 and 240 GHz as well as NMR techniques to exploit complex biological phenomena, such as protein aggregation and folding, lipid membrane dynamics and the supramolecular structure and function of membrane-embedded proteins. We have strong expertise in NMR spectroscopy and imaging, and we are also interested in visualizing and monitoring chemical and biological processes. Find out more in the research section.

News

* New professional development program called WiChE-PD launched by Dr. Katherine Stone helps to strengthen the presentation skills of graduate students in the UCSB Chemistry department.

* UCSB Mini-Symposium on Magnetic Resonance of Macromolecules and Materials, Dec. 10, 2010. See schedule here.

* Check out the Han lab on the cover of the May 2010 Journal of Magnetic Resonance! Read the article here.

* Our recent paper titled "Ultrasensitive Detection of Interfacial Water Diffusion on Lipid Vesicle Surfaces at Molecular Length Scales" was selected for the cover of the December 2009 Journal of the American Chemical Society! Read the article here.

* One of our papers was also showcased as a "Hot Article" in Phys Chem Chem Phys on June 29, 2009. Check it out!

* Some of our work was featured in an article on the cover of Chemical and Engineering News, Oct 27 2008. Read it here.

Han Group 2011

Department of Chemistry and Biochemistry
University of California
Santa Barbara, CA 93106-9510
Labs: Chem 3201, 3215
Offices: Chem 3118, 3219, 3223